Many of us are mindful of the reality that slimming is actually a mega-dollar industry. With millions, or even billions of people spanning various ages struggling to shed weight, and incredibly few pharmaceutically effective medications open to assist them, the desperate public will literally clutch at straws.
Every week sees the launch of your new “miracle” weight loss pill or potion and a “surefire” diet sure to help believers shed kilos like magic.
Recently weight loss by dr oz took over as the flavour of year. In the event you search the internet for facts about this exotic fruit extract you will end up assured that it is finally the miracle we have all been waiting for, that can produce dramatic weight loss. Endorsements by various TV personalities along with other luminaries have put into the allure of Garcinia cambogia slimming products.
Based on a newly released local study through the Tshwane University of Technology (TUT) “this small fruit, similar to a pumpkin in looks, is currently most popularly used and widely advertised as being a weight-loss supplement”.
The comprehensive overview from TUT shows that research indicates that “the extracts in addition to (-)-hydroxycitric acid (HCA), a primary organic acid component of the fruit rind, exhibited anti-obesity activity”. Additionally, it regulates the serotonin levels relevant to satiety, leading to reduced diet.
“According to clinical trial reports, Garcinia extracts were good for obese individuals most of the time. Moreover, studies on the toxicity and observations during numerous studies indicate that Garcinia is safe for use. A lot of the negative reports happen to be relevant to instances when multi ingredient formulations were consumed as well as the effect could stop being attributed to a unique ingredient.”
The study does, however, caution against an increase in serotonin, particularly in people who take medicines which can be already increasing serotonin levels, including SSRIs. Research in to these effects is not conducted.
“Moreover, regulatory authorities must provide and enforce legislation requiring the compulsory basic safety demonstration of supplements pre-marketing and develop post-marketing surveillance systems,” the research concluded.
Dr Ingrid van Heerden, a registered dietitian, is of opinion that people needs to be cautious of how does garcinia work, since it has not undergone rigorous testing. What follows is reviewed information from her pen, including her final verdict:
Often, once someone that wants, or needs to shed pounds, is hooked on the commitment of a slim, sexy figure, these are sucked in the deception. When the drops, wafers or powders don’t work, well then it is the fault in the user who did not abide by one or other often impossible instruction such as “stick into a 500 kcal/day diet” or “drink 5 litres water a day”, never those of the dietary plan pill.
When eventually science and legislation catch up with the makers, they calmly take product A from the market, change their formulation slightly, affect the name to product B, and after that blithely sell product B utilizing the same advertising gambits as before, raking from the money and pulling the wool over everyone’s eyes once again.
In keeping with the ever-changing slimming product ranges, there are actually what you can call “ingredients of year” (sometimes an ingredient may last for only 3 to 6 months, however, some have longer life spans, and after that naturally some are resurrected every 2 to 3 years).
We have had apple cider vinegar (which contains made many a comeback throughout the years), green tea extract (which includes earned some merit in scientific studies), hoodia (which just does not have the ability to produce the research results that can make it a front-runner), willow bark (or salicylic acid which is perfect for pains and aches yet not as efficacious for slimming), and traditional caffeine (that features a diuretic effect thus helping you to slim down till you replenish the water within your body, in addition to a stimulant effect when taken in large quantities that can be potentially dangerous), to call but a couple of.
While it is perfectly entirely possible that more extensive and well controlled scientific studies will disclose that this extract of Garcinia cambogia that contains a chemical called hydroxycitric acid (HCA) can assist weight-loss, we are presently not yet sure how this tamarind or brindall berry or brindleberry or Garcinia gummi-gutta works, what side-effects it may or may not have and what dosage is required to achieve really significant weight-loss.
Having Said That I hear you say: “For once we have a number of scientific studies that were conducted with Garcinia cambogia, so what’s the situation?”
Well a number of the studies did not show any weight reduction differences between patients who took Garcinia pills and those that took dummy pills, while other studies did show variations in fat loss with the subjects taking pills containing Garcinia losing a little more weight than others that did not (Marquez et al, 2012).
A number of these weight-loss differences were not quite exciting either, therefore we can’t say for certain that Garcinia cambogia does promote weight loss. It also seems likely that this is not the wonder pill it really is made out to be.
In addition, lots of the studies conducted to date are already flawed (Critchley, 2013) . What this means is for example that in one study the control and experimental subjects were not well matched (i.e. they did not have the same starting weight, age, number of body fat etc.), during other studies too few subjects were used for your leads to be significant.
To the results of studies to get plausible one must compare “apples with apples” (i.e. well-matched subjects and controls) and you also need more than just some subjects to make the identical result.
On the positive side, we are able to point out that there exists some evidence that Garcinia cambogia products may aid weight reduction over a period of 12 weeks. No research has been conducted for prolonged periods as yet (Marquez et al, 2012), and this is thought to be a drawback.
Addititionally there is at present a disagreement regarding the safety of pills containing Garcinia cambogia – one selection of researchers slates the pills as dangerous and hepatotoxic (causing liver damage) (Kim et al, 2013), while another group refutes this (Clouatre & Preuss, 2013). Marquez and his coworkers (2012) suggest that “at the doses usually administered, no differences happen to be reported regarding unwanted effects or adverse events (those studied) in humans between individuals treated with G. cambogia and controls.”
Ano Lob (2009), a public health consultant in the usa has published a stern warning with regards to the hepatotoxicity of a weight loss product called “Hydroxycut”, that contains Garcinia cambogia. This writer collected case reports of patients who developed liver toxicity linked to the above mentioned fat loss product.
Evidently approximately one million units of the hydroxycitric acid product are sold per year in the us. The patients who developed hepatotoxicity reported signs and symptoms of fatigue, nausea, vomiting, cramps, fever, chills, abdominal pain, and jaundice.
While the number of hepatotoxicity cases reported were not many, Lob points out that monitoring of adverse events associated with vitamin supplements like these weight reduction products is woefully inadequate in the us (as is the case in many other countries, including South Africa), with the FDA only receiving about 1% of the negative reports.
In accordance with Lob (2009), the Poison Control Centres in the USA are more inclined to receive reports of adverse events linked to health supplements but are not equipped to coordinate such findings.
He cites the truly sobering illustration of something called “Metabolife 356″ which had been sold as a fat loss supplement in the united states. Lob’s states that this manufacturers received 14 000 reports over a period of five-years that documented “serious adverse events associated with their ephedra-containing product” which dexrpky17 heart attacks, strokes, convulsions and fatalities.
The makers failed to inform the FDA or other US government authority of the reports. As astounding as this might sound, manufacturers of dietary supplements are not necessary to meet some of the specifications that are strictly enforced in relation to food and pharmaceutical products (medicines), to allow them to use this “ethical loophole” never to publish reports of negative and harmful events.
Eventually these events came to light and ephedra-containing products for slimming as well as other uses were banned in the USA.
The implication contain in Lob’s warning is that HCA or Garcinia cambogia extract will also be potentially toxic unless sufficient, reliable evidence towards the contrary is produced available.
With the present moment, we have no idea enough about slimming goods that contain warning garcinia cambogia to freely recommend its use. I tend to go along with Astell and coworkers (2013) who conducted a systematic review of double blind randomised controlled numerous studies to gauge the evidence on the efficacy of current vitamin supplements accustomed to control appetite and/or weight.
These authors figured that “According on the finding from this systematic review, the evidence will not be convincing in demonstrating that a lot of nutritional supplements used as appetite suppressants for weight loss in the treatment of obesity are effective and safe.”
Basically we wait for more extensive and conclusive evidence obtained with larger variety of well-matched test subjects treated for longer periods with the “gold standard” of double blind randomised controlled numerous studies, rather stay away from any weight-loss supplement that is not tested thoroughly.